Critical Reviews in Immunology · 2001 · 92 citations · 0 references
MedicineMolecular BiologyOncologyGenitourinary OncologyMolecular OncologyProstate DiseaseAndrogen Deprivation TherapyBiomarkers In Genitourinary CancerEndocrine Tumor GeneticsProstate CancerProstate PathologyProstate PhysiologyProstate Cancer Hormonal TherapyProstate Cancer Hormone TherapyProstate Cancer ImmunotherapyProstate Cancer TheranosticsProstate-specific Antigen - Targeted TherapyProstate-specific Membrane Antigen TargetingPsma Targeting LigandsPsma-targeted Therapy
Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This review discusses the historical background, biochemical characteristics, gene regulation, potential for targeting, tissue localization, and a novel T-body strategy.