Ulcer healing properties of different extracts of Origanum majorana in streptozotocin-nicotinamide induced diabetic rats

Abstract

The aim of the present investigation was to evaluate the ulcer healing properties of different extracts of Origannum majorana, viz., hydrodistilled volatile oil (OMO), methanolic (OMM) and aqueous extract (OMW) in streptozotocin-nicotinamide induced diabetic rats. All the extracts were administered in different doses (100, 200 and 400 mg/kg, p.o.) to investigate the ulcer healing potential. Streptozotocin (STZ; 65 mg/kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non-insulin dependent diabetes mellitus in rats. Aspirin (200 mg/kg, i.p.) was administered for initial 7 d to induce gastric ulcerations in the diabetic rats. Various biochemical markers of blood and tissue origin were estimated to compare the ulcer healing potential of these extracts. The OMO and OMM exhibited dose dependent significant (P<0.01) ulcer healing property than the OMW. Additionally, the antidiabetic property of OMO and OMM was better than OMW. The OMO and OMM of Origanum majorana leaves can prove to be beneficial in the concomitant treatment of gastric ulcers and diabetes.