Concepedia

Protective effects of atorvastatin in rat models of acute pulmonary embolism: Involvement of matrix metalloproteinase-9*

Débora C. Souza-Costa, Lívia Figueiredo-Lopes, José C. Alves‐Filho, Maria C. Semprini, Raquel F. Gerlach, Fernando Q. Cunha, José E. Tanus‐Santos

Critical Care Medicine · 2006 · 77 citations · 39 references

DOI

Abstract

These results suggest that pretreatment with atorvastatin attenuates APE-induced pulmonary hypertension and increases 24-hr survival rate by mechanisms that result in attenuated increases in lung activated MMP-9 after APE.

References

39

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

Ulrich Laufs, Vito La Fata, Jorge Plutzky et al. · Circulation · 1998 · 1.8K citations · Full text

HMG-CoA Reductase Inhibitors Reduce MMP-9 Secretion by Macrophages

Stefano Bellosta, D P Via, M. Canavesi et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1998 · 509 citations · Full text

HMG-CoA Reductase Inhibitors Improve Endothelial Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species

Ulrich Laufs, Anselm T. Bäumer, Kirsten Müller et al. · Hypertension · 2001 · 458 citations · Full text

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice

Ulrich Laufs, Karen Gertz, Paul L. Huang et al. · Stroke · 2000 · 387 citations · Full text

Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes

Gabor M. Rubanyi, Elena Ho, Elinor H. Cantor et al. · Biochemical and Biophysical Research Communications · 1991 · 362 citations

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