Preparation of ¹¹C‐nitromethane and an example of its use as a radiolabeling precursor

Abstract

Abstract No‐carrier‐added 11 C‐nitromethane has been prepared from 11 C‐methyl iodide in a one‐pot reaction by use of silver or sodium nitrite in different solvents. A conversion of up to 87% was obtained within 3 min. It could easily be distilled from high‐boiling solvents to another reaction vessel (140°C, 3 min). Its potential as a radiolabeling precursor in condensations with aldehydes was shown in the synthesis of 11 C‐β‐nitrostyrene (85% conversion after 3–5 min).