Occupational and Environmental Medicine · 1969 · 44 citations · 1 references
Veterinary MedicinePharmacologyToxicologyBiochemical PharmacologyHepatotoxicologyMechanisms Of ToxicityChemical-induced HepatotoxicityDrug DispositionHepatic PathophysiologyHepatic ToxicityHepatotoxicity MechanismsLiver DiseaseDrug-induced Hepatic NecrosisDrug-induced Hepatocellular NecrosisHepatotoxic MechanismsLiver Enlargement AssessmentLiver Toxicity AssessmentLiver Toxicity MechanismsSingle-dose Administration
<b>Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968).</b><i>Brit. J. industr. Med.,</i><b>26,</b> 335-337. <b>Effects of carbon disulphide on the liver of rats.</b> Normal rats surviving a single oral dose of carbon disulphide (CS<sub>2</sub>) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS<sub>2,</sub> the LD<sub>50</sub> does not change but liver necrosis is produced.
1