Publication | Closed Access
Microbial transformation of racemic hydantoins to <scp>D</scp>‐amino acids
162
Citations
11
References
1981
Year
EngineeringBiosynthesisBiochemical EngineeringNatural Product BiosynthesisRacemic HydantoinsBiochemistryBiocatalysisDiversity-oriented SynthesisMolecular MicrobiologyNatural Product SynthesisD ‐Amino AcidsBiomolecular EngineeringNatural SciencesEnzyme CatalysisBiotechnologyMicrobiologySynthetic ChemistryComplete TransformationMicrobial Genetics
Abstract It has been shown that resting cells of Agrobacterium radiobacter catalyze a sequence of two stereospecific hydrolytic reactions leading to the complete transformation of racemic hydantoins to D ‐amino acids. This report describes some properties of this new biocatalyst and its potential application for the production of some D ‐amino acids, which are used as intermediates in the preparation of semisynthetic penicillin and cephalosporins.
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