Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Sanford P. Markey, Jan N. Johannessen, Chuang C. Chiueh et al. · Nature · 1984 · 780 citations

Medicine, Neuroscience, Pharmacology +11

MPTP: A neurotoxin producing a parkinsonian syndrome

Marianne Fillenz · Neurochemistry International · 1987 · 123 citations

Life Sciences, Neurobiology, Neuroscience +12

Hepatic Aldehyde Oxidase

K.V. Rajagopalan, Philip Handler · Journal of Biological Chemistry · 1964 · 121 citations · Full text

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Kazuhiro Chiba, Lisa A. Peterson, Kay Castagnoli et al. · PubMed · 1985 · 118 citations

Medicine, Pharmacology, Toxicology +12

Blood‐Brain Barrier Monoamine Oxidase: Enzyme Characterization in Cerebral Microvessels and Other Tissues from Six Mammalian Species, Including Human

Raj N. Kalaria, Sami I. Harik · Journal of Neurochemistry · 1987 · 117 citations

Medicine, Neuroscience, Pharmacology +15