DIVERSOMER^TM technology: Solid phase synthesis, automation, and integration for the generation of chemical diversity

Abstract

Abstract The drug discovery process depends upon the synthesis and testing of thousands of compounds to bring a new drug through discovery, clinical testing, development, and FDA approval. Recent advances in high throughput screening have created the need for the accelerated synthesis of small organic molecules. By combining solid phase chemistry, organic synthesis, and automation with a unique apparatus capable of performing techniques common to organic synthesis, “libraries” of organic compounds (DIVERSOMERS TM ) are efficiently generated. This was demonstrated by the multiple simultaneous synthesis of 40 hydantoins and 40 benzodiazepines, related to Dilantin® and Valium®, respectively. © 1994 Wiley‐Less, Inc.