Radiation Research · 1989 · 46 citations · 18 references
MedicineCancer BiologyCell BiologyRadiation BiophysicsRadiation PhysicsRadiobiologyBiological Effects Of RadiationCellular Radiation ResponseLinear Energy TransferRadiation BiologyRadiation CarcinogenesisRelative Biological EffectivenessEnergy TransferIon Beam IrradiationIonizing Radiation CarcinogenesisIonizing Radiation EffectsLinear Energy Transfer EffectsMorphological TransformationNeoplastic Cell MorphologyRadiobiological Response
We have studied the induction of morphological transformation by heavy ions. Golden hamster embryo cells were irradiated with 95 MeV 14N ions (530 keV/microns), 22 MeV 4He ions (36 keV/microns), and 22 MeV 4He ions with a 100-microns Al absorber (77 keV/microns) which were generated by a cyclotron at the Institute of Physical and Chemical Research in Japan. Colonies were considered to contain neoplastically transformed cells when the cells were densely stacked and made a crisscross pattern. It was shown that the induction of transformation was much more effective with 14N and 4He ions than with gamma or X rays. The relative biological effectiveness (RBE) relative to 60Co gamma rays was 3.3 for 14N ions, 2.4 for 4He ions, and 3.3 for 4He ions with a 100-microns Al absorber. The relationship between RBE and linear energy transfer was qualitatively similar for both cell death and transformation.
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Neoplastic Cell Transformation by Heavy Charged Particles
T. C. Yang, Laurie M. Craise, Mantong Mei et al. · Radiation Research · 1985 · 183 citations
Mutation and inactivation of mammalian cells by various ionising radiations
Roger Cox, John Thacker, D.T. Goodhead et al. · Nature · 1977 · 161 citations
Medicine, Cell Biology, Genetics +12