Antidiarrhoeal activity of the methanolic fraction of the extract of unripe fruits of <i>Psidium guajava</i> Linn.

Abstract

Abstract The methanolic fraction of the extract of unripe fruits of Psidium guajava was found to possess significant antidiarrhoeal activity. The fraction decreased gastric motility in an experimental animal model and inhibited acetylcholine release from isolated guinea‐pig ileum. On microbial screening the fraction was found to inhibit significantly the growth of different strains of Shigella spp. and Vibrio cholerae .