Concepedia

Comparison of Next-Generation Sequencing and Mutation-Specific Platforms in Clinical Practice

John W. J. Hinrichs, W.T.M. van Blokland, Michiel J. Moons, Remco D. Radersma, Joyce H. Radersma‐van Loon, Carmen M. A. de Voijs, Sophie B. Rappel, Marco J. Koudijs, Nicolle Besselink, Stefan M. Willems,

American Journal of Clinical Pathology · 2015 · 46 citations · 20 references

DOIFull text

Open access

Abstract

Sensitivity for detecting mutations was highly comparable among all platforms. The choice for either a dedicated genotyping platform or an NGS platform is basically a trade-off between speed and genetic information.

References

20

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

Tony Mok, Yi‐Long Wu, Sumitra Thongprasert et al. · New England Journal of Medicine · 2009 · 8.2K citations · Full text

An integrated semiconductor device enabling non-optical genome sequencing

Jonathan M. Rothberg, Wolfgang Hinz, Todd M. Rearick et al. · Nature · 2011 · 2.1K citations · Full text

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

Jeffrey A. Sosman, Kevin B. Kim, Lynn M. Schuchter et al. · New England Journal of Medicine · 2012 · 2.1K citations · Full text

Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

David A. Eberhard, Bruce E. Johnson, Lukas C. Amler et al. · Journal of Clinical Oncology · 2005 · 1.5K citations · Full text

Performance comparison of benchtop high-throughput sequencing platforms

Nicholas J. Loman, Raju Misra, Timothy J. Dallman et al. · Nature Biotechnology · 2012 · 1.3K citations

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