Oral but Not Parenteral Aspirin Upregulates COX-2 Expression in Rat Stomachs

Abstract

ASA given p.o. caused damage in the stomach, together with the up-regulation of COX-2 expression, and this expression may be due to the topical irritative action, rather than being a result of PG deficiency. The expression of COX-2 after indomethacin is associated with gastric hypermotility due to PG deficiency.