The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury

Abstract

The results demonstrated an important role for the IL-1R-mediated MyD88-dependent signalling pathway in myocardial I/R injury. The data suggest that modulation of the IL-1R/MyD88 interaction could be a strategy for reducing myocardial ischaemic injury.