PubMed · 1990 · 12 citations · 0 references
Life SciencesBiochemistryChemistryAnalytical ChemistryNucleic Acid BiochemistryNucleic Acid ChemistryBioinorganic ChemistryDna ChemistryDna StructureNucleic Acid StructureDna InteractionsDna Tertiary StructureIntra Chain InteractionsIon Effects In Nucleic Acid StructureIon Effects On Nucleic AcidsNucleic Acid Base PairingViscosityVoltammetry
The interaction of Pb(II) ions with calf-thymus DNA was studied by differential pulse polarography, sweep voltammetry, cyclic voltammetry, chromatography on hydroxyapatite and viscosity measurements. Pb(II) ions may interact with nucleic acid via phosphate groups causing some stabilization of the DNA structure. However, the more specific interaction occurs with nucleic bases. The latter interaction destabilizes the nucleic acid structure and leads to inter- and intra-chain binding.