Concepedia

Proinflammatory Effects in Experimental Mesangial Proliferative Glomerulonephritis of the Immunosuppressive Agent SDZ RAD, a Rapamycin Derivative

Catherine Daniel, Ruth Ziswiler, Brigitte M. Frey, Marc Pfister, Hans‐Peter Marti

Nephron Experimental Nephrology · 2000 · 54 citations · 20 references

DOI

Abstract

Some caution is warranted for the use of SDZ RAD in inflammatory glomerular diseases, since it accentuated glomerular damage induced by anti-Thy1.1 antibodies.

References

20

SDZ RAD, A NEW RAPAMYCIN DERIVATIVE

W. Schüler, Richard Sedrani, Sylvain Cottens et al. · Transplantation · 1997 · 536 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

Richard J. Johnson, Hiroyuki Iida, Charles E. Alpers et al. · Journal of Clinical Investigation · 1991 · 459 citations · Full text

, , +23

Increased synthesis of extracellular matrix in mesangial proliferative nephritis

Jürgen Floege, Richard J. Johnson, Katherine Gordon et al. · Kidney International · 1991 · 264 citations · Full text

, , +7

Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat.

Wilma M. Bagchus, Philip J. Hoedemaeker, Jan Rozing et al. · PubMed · 1986 · 261 citations

Quantitative and qualitative studies of antibody–induced mesangial cell damage in the rat

Tadashi Yamamoto, Curtis B. Wilson · Kidney International · 1987 · 201 citations · Full text

, , +8