Targeting Pro-Apoptotic TRAIL Receptors Sensitizes HeLa Cervical Cancer Cells to Irradiation-Induced Apoptosis

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

Fred Bunz, Paul M. Hwang, Chris Torrance et al. · Journal of Clinical Investigation · 1999 · 1.1K citations · Full text

Medicine, Cancer Biology, Oncology +17

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

Arul M. Chinnaiyan, Uttara Prasad, Sunita Shankar et al. · Proceedings of the National Academy of Sciences · 2000 · 529 citations

Medicine, Oncology, Radiation Oncology +17

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Rishu Takimoto, Wafik S. El‐Deiry · Oncogene · 2000 · 360 citations

Life Sciences, Genetics, Molecular Biology +9

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

Pedro Aza‐Blanc, Christopher L. Cooper, Klaus W. Wagner et al. · Molecular Cell · 2003 · 345 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Phase I Pharmacokinetic and Biologic Correlative Study of Mapatumumab, a Fully Human Monoclonal Antibody With Agonist Activity to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor-1

Anthony W. Tolcher, Monica Mita, Neal J. Meropol et al. · Journal of Clinical Oncology · 2007 · 311 citations · Full text

Medicine, Oncology, Pharmacology +17