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Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus11Abbreviations: AA, arachidonic acid; [Ca2+]i, cytosolic free calcium concentration; cPLA2, cytosolic phospholipase A2; C5a, complement factor C5a; FLAP, 5-LO-activating protein; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; IP3, inositol trisphosphate; 5-LO, 5-lipoxygenase; LT, leukotriene; MAPK, mitogen-activated protein kinase; mAb, monoclonal antibody; PAF, platelet-activating factor; and Ze339, CO2 estract of petasites hybridus.