Advanced Synthesis & Catalysis · 2004 · 370 citations · 234 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCoordination ChemistryLigand-based DesignMetal-ligand BondingAllylic SubstitutionAsymmetric CatalysisAsymmetric Catalyst DesignChiral Catalyst DesignEnantioselective Catalyst DesignLigand DesignTransformations
Abstract In this review, an attempt is made to systemise the rôle which bidentate phosphinamine (P,N) ligands play in asymmetric catalysis. The ligands will be classified, not by the reaction to which their metal complexes have been applied, but by the nature of their donor atoms. In this manner the development of ligand architectural design can be more easily monitored. The asymmetric transformations to which metal complexes of these ligands have been applied include among others, palladium‐catalysed allylic substitutions, copper‐catalysed 1,4‐additions to enones and rhodium‐catalysed hydroboration of vinylarenes. Excellent enantioselectivities, regioselectivities and reactivities have been achieved in each of these processes.
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