<i>In vivo</i> siRNA delivery with dendritic poly( <scp>l</scp> -lysine) for the treatment of hypercholesterolemia

Abstract

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.