Invasion of erythrocytes <i>in vitro</i> by <i>Plasmodium falciparum</i> can be inhibited by monoclonal antibody directed against an S antigen

Abstract

A monoclonal antibody has been produced which binds to the heat stable S antigen present in the FCQ-27/PNG isolate of Plasmodium falciparum. This monoclonal antibody also inhibits the invasion in vitro of erythrocytes by malarial merozoites thus demonstrating that the S antigens of Plasmodium falciparum may be a target of protective immune responses.