Publication | Closed Access
An Efficient Synthesis of Phenol via CuI/8-Hydroxyquinoline-Catalyzed Hydroxylation of Aryl Halides and Potassium Hydroxide
30
Citations
0
References
2010
Year
Chemical EngineeringMixed Solvent SystemEngineeringCui/8-hydroxyquinoline-catalyzed HydroxylationAryl IodidesOrganic ChemistryCui/8-hydroxyquinoline-catalyzed Direct HydroxylationCatalysisEfficient SynthesisChemistryPotassium HydroxideOrganometallic CatalysisAsymmetric CatalysisSynthetic Chemistry
The CuI/8-hydroxyquinoline-catalyzed direct hydroxylation of aryl iodides with KOH takes place at 100 ˚C in a mixed solvent system (t-BuOH-DMSO-H2O), providing the corresponding phenols in great diversity. Aryl bromides are found to be rather less reactive under these reaction conditions.