Aggregating Human Platelets Stimulate Expression of Vascular Endothelial Growth Factor in Cultured Vascular Smooth Muscle Cells Through a Synergistic Effect of Transforming Growth Factor-β <sub>1</sub> and Platelet-Derived Growth Factor <sub>AB</sub> - Concepedia

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Aggregating Human Platelets Stimulate Expression of Vascular Endothelial Growth Factor in Cultured Vascular Smooth Muscle Cells Through a Synergistic Effect of Transforming Growth Factor-β <sub>1</sub> and Platelet-Derived Growth Factor <sub>AB</sub>

DOI Full Paper Access

32

Citations

28

References

1999

Year

Nicola Kronemann, Anne Bouloumié, S. Bassus, C.M. Kirchmaier, Rudi Busse, Valérie B. Schini‐Kerth

Abstract

Aggregating human platelets induce VEGF mRNA expression in cultured SMC and the subsequent release of VEGF protein. This effect can be attributed to a supra-additive action of PDGF(AB) and TGF-beta(1) and may represent a novel mechanism by which platelets contribute to the recovery of the endothelial lining at sites of balloon-injured arteries.

References

	Year	Citations

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