The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease

TLDR

The study aims to determine the prevalence of autoimmune disease and circulating autoantibodies in women with vulvar lichen sclerosus and erosive lichen planus and compare these rates to a control population. In a controlled, age‑ and sex‑matched study, 190 LS, 126 LP, and 922 female controls were recruited from Oxfordshire vulval clinics and the community, and personal/family autoimmune history and autoantibody panels were assessed to evaluate the presence of autoimmune disorders and circulating autoantibodies. Autoimmune disorders were significantly more frequent in LS (28% vs 9%) and erosive LP (29% vs 9%) patients, and circulating autoantibodies were more common in LP (41% vs 20%), confirming an association between these vulvar conditions and autoimmune disease.

Abstract

Objective: To investigate the prevalence of autoimmune disease and circulating autoantibodies in women with lichen sclerosus (LS) and erosive lichen planus (LP) of the vulva and to compare these with a control population.Design: Age-and sex-matched controlled study. Setting:The vulval clinics in Oxfordshire, England, for patients with LS and LP.Healthy controls were recruited from the hospital and community.Patients: A total of 190 women with the typical features of adult-onset LS of the vulva, 126 women with adult-onset erosive LP of the vulva, and 922 female controls (of whom 230 were examined).Interventions: Personal history of autoimmune disorder for patients and controls, family history of autoimmune disorder for vulval LS and LP cohorts, and an autoantibody screen. Main Outcome Measures:The presence or absence of a personal or family history of autoimmune disorder, and the presence or absence of 1 or more circulating autoantibodies. Results:The mean ages of patients with LS, patients with erosive LP, and control patients were 63, 61, and 61 years, respectively.The mean age of the 230 controls examined (including those who had serum autoantibodies assayed) was 62 years.Autoimmune disorders were more frequent in patients with erosive LP compared with controls (29% vs 9%; PϽ .001) and in those with LS compared with controls (28% vs 9%; P Ͻ.001).Circulating autoantibodies were more frequent in those with erosive LP compared with controls (41% vs 20%; P Ͻ.001). Conclusion:This study demonstrates an association of autoimmune disorder and autoantibodies with erosive LP of the vulva and confirms the autoimmune associations of vulval LS.