Optimal Dosing of Piperacillin‐Tazobactam for the Treatment of <i>Pseudomonas aeruginosa</i> Infections: Prolonged or Continuous Infusion?

Abstract

Both prolonged- and continuous-infusion strategies improved the pharmacodynamics of piperacillin-tazobactam over those of traditional 30-minute intermittent-infusion regimens. Prolonged- and continuous infusion regimens that contained the same daily doses of piperacillin had similar likelihoods of bactericidal exposure. Thus, the selection of dosing strategy depends on the availability of intravenous access versus the convenience of once-daily administration.