Endocrinology · 1932 · 27 citations · 0 references
MedicineEndocrinologyObstetricsMaternal-fetal MedicineObstetric ComplicationsReproductive EndocrinologyMaternal Medical Complications In PregnancyMaternal Medical ConditionsPregnancyPregnancy EndocrinologyVomiting ManagementAdrenal Cortex FunctionAdrenal Cortex PhysiologyGlandular HypertrophyMaternal Hypothalamic-pituitary-adrenal AxisNausea In PregnancyPregnancy-associated Nausea ManagementPregnancy-related NauseaVomiting In Pregnancy
The association of suprarenal cortical insufficiency with gastro-intestinal disturbances as shown by many recently reported laboratory experiments in dogs, coupled with the fact that the adrenal cortex hypertrophies in pregnancy suggested that the temporary and relative adrenal cortical insufficiency might be the etiological factor in the nausea and vomiting so common in the first trimester of pregnancy. It is assumed that the natural hypertrophy of the adrenal cortex incidental to pregnancy does not reach sufficient proportions to fully care for the mother’s increased metabolic load until the end of the third month when the vomiting usually ceases. Six consecutive cases of the use of adrenal cortex material are herewith reported.