Residual amblyopia in recruits to the British Army.

Abstract

effect; the mechanism of this is unknown but is associated with prolongation of the QT interval.3There is little doubt that in the two cases reported here amiodarone exerted an antiarrhythmic effect within a few hours of the first oral dose.Possibly previous treatment with other antiarrhythmic agents had in some way sensitised the myocardium to the effects of amio- darone.The prolongation of the QT interval suggests that in our patients oral amiodarone produced an acute pharmacological effect similar to that seen after intravenous administration.Our observations cannot be explained on the basis of current knowledge of the pharmacokinetics of oral amiodarone and highlight the need for further investigation of its mode of action.