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Multicenter comparison of in vitro activities of FK-037, cefepime, ceftriaxone, ceftazidime, and cefuroxime

John A. Washington, Ronald N. Jones, E. Gerlach, P R Murray, S D Allen, C C Knapp

Antimicrobial Agents and Chemotherapy · 1993 · 41 citations · 6 references

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Abstract

In a multicenter study, the MICs of FK-037 for 90% of the strains tested (MIC90s) were < or = 1 microgram/ml for members of the family Enterobacteriaceae other than Citrobacter freundii, Enterobacter spp., and Serratia marcescens. Activity against Pseudomonas aeruginosa was variable, with a MIC50 and a MIC90 of 4 and 32 micrograms/ml, respectively. Relative to cefepime, however, FK-037 was less active against ceftazidime-resistant isolates of Enterobacter cloacae. The MIC90 of FK-037 for methicillin-resistant staphylococci was > 16 micrograms/ml.

References

6

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J Fung-Tomc, Thomas J. Dougherty, F J DeOrio et al. · Antimicrobial Agents and Chemotherapy · 1989 · 73 citations

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In vitro and in vivo antibacterial activities of FK037, a novel parenteral broad-spectrum cephalosporin

Kwung P. Fu, Barbara D. Foleno, S.C. Lafredo et al. · Antimicrobial Agents and Chemotherapy · 1993 · 37 citations

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In vitro activity and beta-lactamase stability of FK-037, a parenteral cephalosporin

Harold C. Neu, N X Chin, Hsien‐Bin Huang · Antimicrobial Agents and Chemotherapy · 1993 · 29 citations

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Activity of cefepime, ceftazidime, and ceftizoxime against mutants of Enterobacteriaceae and <i>Pseudomonas aeruginosa</i> derepressed for Class I β-lactamse

C C Knapp, John A. Washington · Journal of Antimicrobial Chemotherapy · 1989 · 12 citations

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In-vitro activity of FK-037, a new parenteral cephalosporin

Ronald N. Jones, Mary S. Barrett, Meridith E. Erwin · Journal of Antimicrobial Chemotherapy · 1994 · 12 citations

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