Synthesis of 1‐(1<i>H</i>‐Tetrazol‐5‐yl)‐2<i>H</i>‐isoindole Derivatives through Ugi Four‐Component and Silver‐Catalyzed Reactions

Abstract

Abstract A facile and efficient one‐pot, two‐step synthesis of 1,2‐disubstituted 3‐(1 H ‐tetrazol‐5‐yl)‐2 H ‐isoindoles through Ugi four‐component reaction/AgNO 3 ‐catalyzed reaction of 2‐alkynylbenzaldehydes, amines, isonitriles, and Me 3 SiN 3 is described. This transformation proceeds through 5‐ exo‐dig cyclization, [1,3]‐H shift, and [1,5]‐H shift to generate the products in moderate to excellent yields.