Specific IgE determination by RAST compared with skin and provocation tests in allergy diagnosis with birch pollen, timothy pollen and dog epithelium allergens

Abstract

Summary In sixty‐five patients with asthma or allergic rhinitis, intracutaneous tests and provocation tests were performed with birch pollen, timothy pollen and/or dog epithelium allergen. The clinical diagnosis was compared with RAST results obtained with identical allergen preparations for in vivo as well as in vitro testing in two different laboratories. An overall correlation between in vitro and in vivo diagnosis was found in 85% of the cases. It is suggested that a scoring system using the sum of case history score and RAST values could be used for screening allergic patients with different allergens, making in vivo tests necessary only in a limited number of the cases.