Hydrogen‐Bond‐Promoted Palladium Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3‐Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands

Abstract

A DYKAT die hard: A new class of chiral BiSO-P ligands were effective for an unprecedented palladium-catalyzed asymmetric allylic alkylation of indoles with the racemic title acetates through a dynamic kinetic asymmetric transformation (DYKAT). The hydrogen bond formed between the sulfinyl group of the ligand and NH of indole plays an important role in the reaction. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.