Relationship Between Na ⁺ -Ca ²⁺ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium

Abstract

By discriminating failing human hearts according to their diastolic function, we identified different phenotypes. Disturbed diastolic function occurs in hearts with decreased SR Ca2+-ATPase and unchanged Na+-Ca2+ exchanger, whereas increased expression of the Na+-Ca2+ exchanger is associated with preserved diastolic function.