Expression of CYP2A genes in human liver and extrahepatic tissues

Role of human cytochrome P4502A6 in C-oxidation of nicotine.

Masatoshi Nakajima, Takahiko Yamamoto, K Nunoya et al. · Drug Metabolism and Disposition · 1996 · 421 citations

Medicine, Biochemistry, Pharmacology +15

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of <i>N</i>-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

Hiroshi Yamazaki, Yukiharu Inui, Chul‐Ho Yun et al. · Carcinogenesis · 1992 · 399 citations

Medicine, Biochemistry, Pharmacology +13

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

Shigeru Yamano, Jun Tatsuno, Frank J. Gonzalez · Biochemistry · 1990 · 384 citations

Medicine, Biochemistry, Pharmacology +8

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

Pedro M. Fernández‐Salguero, Susan M.G. Hoffman, S. Cholerton et al. · PubMed · 1995 · 296 citations · Full text

Medicine, Genetics, Pharmacology +12

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.

Masatoshi Nakajima, Takahiko Yamamoto, K Nunoya et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 283 citations

Medicine, Biochemistry, Pharmacology +14