Estrogenic and Gonadotrophic Hormone Inhibiting Activity of Some Adrenal Cortical Substances.*

Abstract

Lipo Adrenal Cortex and desoxycorticosterone acetate were found to stimulate uterine growth and to inhibit pituitary gonadotrophic hormone secretion when administered to female rats in relatively small amounts. Adrenal Cortex Extract partially inhibited gonadotrophin secretion but was less than one fourth as effective as the Lipo Adrenal Cortex. Large doses of Compound E failed to inhibit the gonadotrophin secretion. The secretion of gonadotrophic hormone is inhibited in immature rats by steroids in amounts less than those which result in uterine growth.