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Vincristine-Induced Thrombocytosis Studied with <sup>75</sup>Se Selenomethionine
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1972
Year
ThrombopoiesisThrombosisSelenium DeficiencyBlood PlateletMedicineHematologyCell DeathHemostasisPlatelet ProductionVincristine InducesPharmacotherapyPlatelet AntagonistPharmacologyAnticoagulantVincristine-induced Thrombocytosis StudiedPlatelet Count
Thrombocytosis was produced in rats by repeated doses of vincristine over a period of three weeks. Using 75Se Selenomethionine to assess platelet production, evidence was obtained that vincristine induces an increase in the platelet count by causing an increase in thrombopoiesis.