International Journal of Antimicrobial Agents · 2014 · 60 citations · 17 references
PharmacyInfectious DiseasesPharmacotherapyAntimicrobial PharmacologyAntimicrobial PharmacotherapyAntimicrobial StewardshipAntibiotic ResistanceAntimicrobial De-escalationDe-escalation Of Antimicrobial TherapyHospital Antimicrobial StewardshipIntravenous To Oral Switch PoliciesIntravenous-to-oral Switch TherapyDuration Of Antibiotic TreatmentEarly Discharge CriteriaIntravenous To Oral Antibiotic TransitionIntravenous To Oral Switch CriteriaIntravenous-to-oral Antibiotic SwitchMedical Chart ReviewMethicillin-resistant Staphylococcus Aureus TreatmentSkin Infection Antibiotic Stewardship
This retrospective observational medical chart review aimed to describe country-specific variations across Europe in real-world meticillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft-tissue infection (cSSTI) treatment patterns, antibiotic stewardship activity, and potential opportunities for early switch (ES) from intravenous (i.v.) to oral formulations and early discharge (ED) from hospital using standardised data collection and criteria and economic implications of these opportunities. Patients were randomly sampled from 12 countries (Austria, Czech Republic, France, Germany, Greece, Ireland, Italy, Poland, Portugal, Slovakia, Spain and the UK), aged ≥18 years, with documented MRSA cSSTI, hospitalised between 1 July 2010 and 30 June 2011, discharged alive by 31 July 2011. Of 1502 patients, 1468 received MRSA-targeted therapy. Intravenous-to-oral switch rates ranged from 2.0% to 20.2%, i.v. length of therapy from 10.1 to 18.6 days and hospital length of stay (LoS) from 15.2 to 25.0 days across Europe. Of 341 sites, 82.9% had antibiotic steering committees, 23.7% had i.v.-to-oral switch antibiotic protocols and 12.9% had ED protocols for MRSA cSSTI. ES and ED eligibility ranged from 12.0% (Slovakia) to 56.3% (Greece) and from 10% (Slovakia) to 48.2% (Portugal), respectively. Potential cost savings per ED-eligible patient ranged from €414 (Slovakia) to €2703 (France). MRSA cSSTI treatment patterns varied widely across countries, but further reductions in i.v. therapy, hospital LoS and associated costs could be realised. These data provide insight into clinical practice patterns across diverse European healthcare systems and identify potential opportunities for local clinicians and policy-makers to improve clinical care and cost-effectiveness of this therapeutic area.
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Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy
Alan D. Tice, Susan J. Rehm, J. R. Dalovisio et al. · Clinical Infectious Diseases · 2004 · 530 citations · Full text