Chemical Modification of Erythromycins. VIII. A New Effective Route to Clarithromycin (6-O-Methylerythromycin A)

Abstract

Selective g-methylation of the C-6 hydroxyl group of erythromycin A could be satisfactorily achieved by using its 9-oxime derivatives as the starting materials.Thus, 6-Q-methylerythromycin A (clarithramycin) was synthesized from 2'-0.3'-N-bis(benryloxycarbonylj-N-demethylerythromycinA v i a its 9-oxime derivative by 6 steps.-