Local Delivery of Chemotherapy Prolongs Survival in Experimental Brain Metastases from Breast Carcinoma

Abstract

Local delivery of BCNU with biodegradable polymers can significantly prolong survival in a murine model of intracranial metastatic breast cancer. Surgical resection and placement of BCNU polymers into the resection cavity may decrease the incidence of local recurrence of breast cancer metastases with minimal morbidity.