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Trimethylamine N-oxide as a precursor of azomethine ylides
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1983
Year
High YieldsVarious Simple AlkenesEngineeringHeterocyclicTrimethylamine N-oxideOrganic ChemistryChemistryLithium Di-isopropylamideSynthetic ChemistryBiomolecular Engineering
The first azomethine ylide devoid of a stabilizing group, generated by treating trimethylamine N-oxide with lithium di-isopropylamide, undergoes a ready [3 + 2] cycloaddition with various simple alkenes to give high yields of the corresponding pyrrolidines.