The Surgical Patient with Brugada Syndrome: A Four-Case Clinical Experience

Abstract

In Brief Brugada syndrome is characterized by a distinctive electrocardiographic pattern (right bundle branch block and ST segment elevation in precordial leads) and a high risk of cardiac arrest for malignant dysrhythmia. The genetic basis is a molecular defect of the cardiac sodium channel and the pattern of inheritance is autosomal dominant. Many factors during general anesthesia (medications, bradycardia, temperature changes) could precipitate malignant dysrhythmia in these patients. Because criteria to identify the surgical patient at high risk for developing malignant dysrhythmia are lacking, we can only speculate about the available studies on nonsurgical patients. We describe four patients during general anesthesia and propose intraoperative and postoperative monitoring (the first 36 h). IMPLICATIONS: Many factors (medications, bradycardia, temperature changes) during general anesthesia could precipitate a malignant dysrhythmia in a patient with Brugada Syndrome. We describe four cases during general anesthesia in our hospital. The data for patients with Brugada syndrome during surgery are minimal. Based on the literature and experience, we propose minimal monitoring requirements intraoperatively and postoperatively.