Promazine Complexes of Transition Metal Ions: Synthesis

Abstract

<b> </b>Psychotherapeutic, antiemetic, and antihistamine activities are exhibited by some of the N- alkylaminophenothiazine derivatives including promazine (P). The N-alkylamine side chain is implicated in the aforementioned pharmacological activities. Several promazine (P.HCl or C<SUB>17</SUB>H<SUB>20</SUB>N<SUB>2</SUB>S.HCl) complexes of the transition metal ions, Zn(II), Cd(II) and Hg(II), have been synthesized. The complexes have been characterized by their elemental analysis, molar conductivity, magnetic susceptibility, UV-Visible, IR and <SUP>1</SUP>H-NMR data. The molecular formulations of the new mononuclear complexes have been proposed. These complexes behave in DMF solutions as 1:1 electrolytes. Molecular structures have been proposed showing a square pyramidal environment around each metal center with an sp<SUP>3</SUP>d hybridization for the five-coordinate complexes, [ZnBr(C<SUB>17</SUB>H<SUB>20</SUB>N<SUB>2</SUB>S.HCl)<SUB>2</SUB>]Br, [CdBr(C<SUB>17</SUB>H<SUB>20</SUB>N<SUB>2</SUB>S.HCl)<SUB>2</SUB>]Br, [CdI(C<SUB>17</SUB>H<SUB>20</SUB>N<SUB>2</SUB>S.HCl)<SUB>2</SUB>]I.H<SUB>2</SUB>O and [HgBr((C<SUB>17</SUB>H<SUB>20</SUB>N<SUB>2</SUB>S. HCl)<SUB>2</SUB>]Br.