Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis # †

Abstract

1q gain and 1p and 17p LOH are early molecular events, whereas gains in 5q and 8q and LOH on 4q and 8p only occur in advanced HCC, and inactivation of the putative suppressor gene, CSMD1, may be the key event in progression of liver cancer.