Preparation of optically active n-butyl(methyl)phenyl-, tert-butyl(methyl)phenyl- and isopropyl(methyl)phenylsilanes from the corresponding silyl chlorides using 2,2′-dihydroxy-1,1′-binaphthyls as resolving agents

Abstract

Enantiomeric silanes 4a, 4b and 4c were obtained from the corresponding racemic silyl chlorides via diastereomeric derivatives with (R)-[1,1′]binaphthalenyl-2,2′-diol; the optical purity of silanes 4a and 4c was determined (>98% ee) by HPLC using a chiral cyclodextrin-based column.