Quantification of <i><scp>HBG</scp></i> m<scp>RNA</scp> in primary erythroid cultures: prediction of the response to hydroxyurea in sickle cell and beta‐thalassemia

Abstract

The fold increase in HBG mRNA in erythroid progenitors was similar to the fold increase in HbF in vivo. Quantification of HBG mRNA in erythroid progenitor cell cultures from patients with SCD and TI is predictive of their clinical response to HU.