Regulatory T-Cell Impairment in Cystic Fibrosis Patients with Chronic <i>Pseudomonas</i> Infection

Abstract

Patients with CF who have chronic P. aeruginosa infection show an age-dependent, quantitative, and qualitative impairment of Tregs. Modulation of Tregs represents a novel strategy to rebalance T-cell responses, dampen inflammation, and ultimately improve outcomes for patients with infective CF lung disease.