Genetic Disparity Between Morphologically Benign Cysts Contiguous to Ovarian Carcinomas and Solitary Cystadenomas

Abstract

Ovarian carcinomas can be distinguished from ovarian cystadenomas and tumors of low malignant potential by p53 mutations. The fact that the mutations were present in histologically benign cysts contiguous to ovarian carcinomas suggests that such cysts are not typical cystadenomas and may carry a genetic predisposition to carcinogenesis that is not present in ordinary cystadenomas.