Penicillin biosynthesis: active site mapping with aminoadipoylcysteinylvaline variants

Abstract

A series of structural variants on the aminoadipoly moiety of the natural precursor of penicillins, δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine, have been synthesised and their effectiveness as substrates for the enzyme isopenicillin N synthetase has been determined.