Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes

Abstract

In this 24-week monotherapy study, sitagliptin was non-inferior to metformin in improving HbA(1c) in treatment-naïve patients with type 2 diabetes. Although both treatments were generally well tolerated, a lower incidence of gastrointestinal-related adverse experiences was observed with sitagliptin.