Hepatitis Associated with Coxsackie Virus Group A, Type 4

Abstract

HERPANGINA is generally associated in man with infection with Group A Coxsackie viruses.1 Less frequently, Coxsackie viruses occur with encephalitis,1 aseptic meningitis2 and ill defined febrile illnesses that are sometimes associated with rash.3 On rare occasions Coxsackie viruses have been recovered from patients with clinical hepatitis4 5 6; in at least 1 of these patients there was an associated rash.6 In 1956 an organism subsequently identified as Coxsackie virus Group A, Type 4, was recovered by one of us (W.L.P.) from the blood of a one-and-a-half-year-old child with clinical hepatitis associated with jaundice and rash. During convalescence at least a sixteenfold . . .