Hazards of central venous catheterization.

Abstract

The abnormal lipid pattern is the first change to occur as hypothyroidism de- velops and the last to disappear on treat- ment, or remains the sole abnormal finding on inadequate therapy as shown in the data presented by Dr. Evered and his col- leagues.Although the lipid alteration is unexplained, it cannot therefore be dis- missed with the words, "the hepatic mechanisms for cholesterol excreion and catabolism are unlikely to be prescient of a future hormone deficiency."3The conclusions regarding T4 dosage, reached as a result of the excellent work by Dr. Evered and his colleagues, are in conflict with mine, based on simpler tests done on a great number of patients.Dr.Evered and his colleagues will warn that over-treated hypothyroid patients will suffer from fragile bones and I will con- tinue to warn that under-treated hypothyroid patients may die of coronary artery disease.-Iam, etc.,