Concepedia

CLINICAL, HORMONAL AND ULTRASTRUCTURE STUDIES OF A VIRILIZING HEPATOBLASTOMA

Emmelianna Kumar, Lata Kumar, IQBAL C. PATHAK, Radharaman Jiban Dash, Vijay V. Joshi

Acta Paediatrica · 1978 · 23 citations · 14 references

DOI

Concepts

Abstract

Virilizing hepatoblastoma was found to be the cause of precocious puberty in a 3 1/4-year-old boy. Both human chorionic gonadotropins and alphafetoprotein in increased amounts were detected in serum and tumor tissue. These substances disappeared from the blood after removal of the tumor. Ultrastructure studies revealed the presence of dense, membrane bound, secretory granules responsible for the hormone production.

References

14

Studies of carcino‐fetal proteins. III. Development of a radioimmunoassay for α‐fetoprotein. Demonstration of α‐fetoprotein in serum of healthy human adults

Erkki Ruoslahti, Markku Seppälä · International Journal of Cancer · 1971 · 278 citations

, , +11

Primary Carcinoma of the Liver in Childhood: An Epidemiologic Study

Robert W. Miller, Judith A. Hill · JNCI Journal of the National Cancer Institute · 1968 · 135 citations

, , +17

Precocious puberty in a boy with hepatoma and circulating gonadotropin

Wellington Hung, Robert M. Blizzard, Claude J. Migeon et al. · The Journal of Pediatrics · 1963 · 93 citations

, , +14

PRECOCIOUS PUBERTY ASSOCIATED WITH HEPATOMA

Robert L. Reeves, Henry Tesluk, Carlos E. Harrison · The Journal of Clinical Endocrinology & Metabolism · 1959 · 78 citations

, , +17

<i>In Vivo</i>and<i>in Vitro</i>Production of Human Chorionic Gonadotropin and Alpha-Fetoprotein by a Virilizing Hepatoblastoma

Glenn D. Braunstein, William E. Bridson, Andrew G. Glass et al. · The Journal of Clinical Endocrinology & Metabolism · 1972 · 68 citations

, , +15